TGF-beta decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells

2009 Fiscal Year Final Research Report

• Project/Area Number: 20890049
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: The University of Tokyo
• Principal Investigator: EHATA Shogo The University of Tokyo, 大学院・医学系研究科, 助教 (90506726)
• Project Period (FY): 2008 – 2009
• Keywords: 遺伝子 / 癌 / シグナル伝達 / 病理学 / 薬剤反応性

Research Abstract

Stem cells in normal tissues and cancer-initiating cells (CICs) are known to be enriched in Side Population (SP) cells. However, the factors responsible for the regulation of expression of ABCG2, involved in efflux of dyes, in SP cells have not been fully investigated. Here, we characterized the SP cells within diffuse-type gastric carcinoma, and examined the effects of TGF-beta on SP cells.

Research Products

• [Presentation] TGF-β diminishes the SP fraction of the diffuse-type gastric cancer cells (2009)
  • Author(s): Shogo Ehata, Ryohei Katayama, Sumie Koike, Yukari Hoshino, Yoko Katsuno, Mitsunobu Kano, Masakazu Yashiro, Kosei Hirakawa, Hiroyuki Aburatani, Naoya Fujita, Kohei Miyazono
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
  • Year and Date: 2009-10-02
• [Remarks] 東京大学・大学院医学系研究科・病因病理学専攻・分子病理学分野ホームページ
  • URL: http://beta-lab.umin.ac.jp/