2009 Fiscal Year Final Research Report

A role of dysregulated glycosylation of hypoxia-inducible factors in the pathogenesis of cardio-renal syndrome

Research Project

Project/Area Number	20890053
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Kidney internal medicine
Research Institution	The University of Tokyo
Principal Investigator	TANAKA Tetsuhiro The University of Tokyo, 保健・健康推進本部, 助教 (90508079)
Project Period (FY)	2008 – 2009
Keywords	心腎連関 / HIF / 糖化修飾
Research Abstract	This study was designed to gain insight into molecular mechanisms in the pathogenesis of the cardio-renal syndrome, from a viewpoint of dysregulated glycosylation of hypoxia-inducible transcription factors. Methylglyoxal (MG) is a highly reactive metabolite and is known to accumulate in chronic kidney disease. In cell culture experiments, MG failed to impact hypoxia response. On the other hand, high glucose dampened cellular hypoxia response by approximately 20%. Results of the present study provide a clue to understanding molecular mechanisms underlying the cardio-renal syndrome as well as the metabolic syndrome.