2009 Fiscal Year Final Research Report
Function analysis and clinical application of AMP kinase in endometrium and endometriosis
| Project/Area Number |
20890058
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
TAKEMURA Yuri The University of Tokyo, 医学部・附属病院, 助教 (00453697)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 子宮内膜 / 子宮内膜症 / AMPキナーゼ |
|---|
| Research Abstract |
AMP kinase (AMPK), a regulator of energy homeostasis of the cell, has anti-inflammatory effects with AMPK phosphorylation of endometrial cells, and I surmised that AMPK was involved in implantation and endometriosis. I detected the increased expression of AMPK in the human endometrium in the implantation period and the decreased expression of AMPK in the endometrium of infertile women, suggesting that AMPK may play a physiological role in the implantation. Contrary to conventional hormonal anti-endometriotic drugs that unavoidably suppress estrogen and ovulation, the present study suggest a unique therapeutic potential for metformin as an anti-endometriotic drug.
|
-
[Journal Article] Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells2010
Author(s)
Kodama A, Yoshino O, Osuga Y, Harada M, Hasegawa A, Hamasaki K, Takamura M, Koga K, Hirota Y, Hirata T, Takemura Y, et al
-
Journal Title
Human Reproduction 3
Pages: 751-6
Peer Reviewed
-
-
-
-
-
-
