2009 Fiscal Year Final Research Report
Role of Maf in osteoblast and adipocytes differentiation
| Project/Area Number |
20890060
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NISIKAWA Keizo Tokyo Medical and Dental University, 医歯学総合研究科, 特任助教 (30516290)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 骨芽細胞 / 脂肪細胞 / 間葉系細胞 / 転写因子 / c-Maf / 骨粗鬆症 / 脂肪髄 / 老化 |
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| Research Abstract |
Mesenchymal stem cells have a multipotent differentiation capacity into osteoblasts and adipocytes. Aging tips this balance in favor of the latter, thus inducing bone loss accompanied by fatty marrow, but the mechanism remains elusive. Here we show that Maf play an important role in bone aging.
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