2009 Fiscal Year Final Research Report
Combination therapy of hypothermia and thrombolysis in acute ischemic stroke
| Project/Area Number |
20890103
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Mie University |
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Principal Investigator |
YATA Kenichiro Mie University, 大学院・医学系研究科, 産学官連携研究員 (40467361)
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| Project Period (FY) |
2008 – 2009
|
| Keywords | 血栓溶解療法 / 血液・脳関門 / 内皮細胞 / t-PA / 低体温療法 |
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| Research Abstract |
Thrombolysis therapy is essentially limited by the short therapeutic window and its potential side effects. The present study investigates whether thrombolysis alone or in combination with hypothermia has beneficial effects after experimental acute ischemic stroke. Hypothermia reduces leukocyte rolling and adhesion, and protects the blood brain barrier.
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