2009 Fiscal Year Final Research Report
Role of a novel anti-inflammatory signaling mediated by EPRAP
| Project/Area Number |
20890111
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
MINAMI Manabu Kyoto University, 医学研究科, 助教 (90511907)
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| Project Period (FY) |
2008 – 2009
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| Keywords | シグナル伝達 / 炎症・免疫 / マクロファージ |
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| Research Abstract |
Macrophages participate in the pathogenesis of many chronic inflammatory diseases including atherosclerosis and cancer. Thus, the regulation of macrophage activation holds a key to understanding the pathophysiology and rational treatment of these conditions.
We previously reported that PGE_2 markedly suppressed inflammatory activation of human and mouse primary macrophages through EP4 receptor and EPRAP, novel EP4 receptor-associated protein. To clarify the molecular mechanisms of EPRAP-mediated anti-inflammatory signaling in macrophages as well as to know the roles of EPRAP in human chronic diseases including atherosclerosis, we have been working on these projects : (1) production of the rabbit polyclonal antibody against human EPRAP, (2) purification of recombinant human EPRAP protein, and (3) generation of EPRAP mutant mice.
Our study would add new insights into the mechanisms that may mitigate unchecked macrophage activation at sites of inflammation, and EP4-EPRAP signaling could be a novel target for the treatment of chronic inflammatory diseases.
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Research Products
(12 results)
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[Journal Article] C-C chemokine receptor 2inhibitor improves diet-induceddevelopment of insulin resistance andhepatic steatosis in mice2010
Author(s)
Tamura, Y., M. Sugimoto, T. Murayama, M. Minami, Y. Nishikaze, H. Ariyasu, T. Akamizu, T. Kita, M. Yokode, H. Arai
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Journal Title
JAtheroscler Thromb 17
Pages: 219-228
Peer Reviewed
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[Journal Article] Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis2008
Author(s)
Okamoto, Y., E.J. Folco, A.K. Wara, M.W. Feinberg, G.K. Sukhova, R.A. Colvin, S. Kihara, T. Funahashi, A.D. Luster, P. Libby
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Journal Title
CircRes 102
Pages: 218-225
Peer Reviewed
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[Journal Article] Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis2008
Author(s)
Okamoto, Y., E.J. Folco M. Minami, A.K. Wara, M.W. Feinberg, G.K. Sukhova, R.A. Colvin, S. Kihara, T. Funahashi, A.D. Luster, P. Libby
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Journal Title
CircRes 102
Pages: 218-225
Peer Reviewed
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