Development of the prevention for the esophageal stenosis after endoscopic resection of all circumferences for early esophageal cancer

2009 Fiscal Year Final Research Report

• Project/Area Number: 20890125
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kobe University
• Principal Investigator: TOYONOGA Takashi Kobe University, 医学部附属病院, 准教授 (40464268)
• Project Period (FY): 2008 – 2009
• Keywords: 早期食道癌 / バイオマテリアルシート / 生体ブタモデル

Research Abstract

In digestive endoscopy field aspiring to less invasive therapy, especially extensive endoscopic submucosal dissection (ESD), the stenosis after ESD is a serious problem. In this study, we examine the prevention for extensive ESD for early esophageal cancer using chitin-containing biomaterial sheets derived from yeast. We succeeded in developing of the esophageal stenosis model after extensive ESD and confirmed the effectiveness of the biomaterial sheets for subcutaneous implantation model using a living pig. In the digestive tract, it was difficult to fix the sheets on the ulcer, we are making the improvement of the raw material and further device.