2009 Fiscal Year Final Research Report
Strategy of macrophage-mediated xenograft rejection through inhibitory signaling to SIRP.
| Project/Area Number |
20890141
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
IDE Kentaro Hiroshima University, 病院, 助教 (50511565)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 異種移植 / CD47 / マクロファージ / 拒絶反応 / 遺伝子導入 |
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| Research Abstract |
We have previously shown that pig CD47 does not interact with human SIRPα, and that human CD47 expression inhibits phagocytosis of porcine cells by human macrophages in vitro. In this study, we investigate the potential of human CD47 expression to promote porcine cell survival in vivo.
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