2009 Fiscal Year Final Research Report
Ischemic preconditioning and remote ischemic preconditioning have protective effect against cold ischemia-reperfusion injury of rat small intestine.
| Project/Area Number |
20890158
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SAEKI Isamu Kyushu University, 大学病院, 医員 (80452762)
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| Research Collaborator |
HAYASHIDA Makoto 九州大学, 大学病院・小児外科, 助教 (70452761)
MATSURA Toshiharu 九州大学, 大学病院・小児外科, 助教 (10532856)
TAGUCHI Tomoaki 九州大学, 大学病院・小児外科, 教授 (20197247)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 移植・再生医療 / 小児外科 / 小腸移植 / 虚血再潅流障害 / Ischemic preconditioning |
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| Research Abstract |
Male Lewis rats weighting 200-300g were used for this study. Rats were allocated into three groups : control (C) ; ischemic preconditioning (IPC) ; or remote ischemic preconditioning (RIPC), followed by ectopic small bowel transplantation. The values of tissue injury were significantly lower in IPC and RIPC groups than in C group at 3 hours after transplantation. Both IPC and RIPC can equally ameliorate ischemia-reperfusion injury after rat intestinal transplantation in early phase.
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