2009 Fiscal Year Final Research Report

Development of prophylactic therapy against sepsis and hepatic failure in rat short bowel models managed with total parenteral nutrition

Research Project

Project/Area Number	20890195
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Pediatric surgery
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	FURUKAWA Taizo Kyoto Prefectural University of Medicine, 医学研究科, 助教 (20515291)
Research Collaborator	KIMURA Osamu 京都府立医科大学, 医学研究科, 准教授 (10315963)
Project Period (FY)	2008 – 2009
Keywords	短腸症候群 / 完全静脈栄養 / 神経ペプチド / サイトカイン / ボンベシン
Research Abstract	The rat short bowel model was established by massive intestinal resection. The animals were managed with total parenteral nutrition and were investigated whether administration of neuropeptide, bombesin, had favorable effect against cholestatic liver dysfunction induced by total parenteral nutrition. During this investigation, technical difficulty was encountered for the maintenance of long-term total parenteral nutrition. As a result, bombesin could suppress bacterial translocation from intestinal mucosa and ameliorate the extent of cholestatic liver dysfunction.

(4 results)