2009 Fiscal Year Final Research Report
Functional analysis of the novel ALS-causative VAPB gene.
| Project/Area Number |
20890216
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
KANEKURA Kohsuke Keio University, 医学部, 助教 (10508568)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | ALS / UPR / VAPB / ER stress |
|---|
| Research Abstract |
The novel ALS-causative gene, VAPB is involved in unfolded protein response, a physiological signal against endoplasmic reticulum (ER) stress. We investigated VAPB function in detail, and demonstrated that wt-VAPB triggers IRE1 to enhance expression of ER chaperons but it suppress PERK pathway. On the other hand, ALS-causative mutant VAPB dominant negatively suppresses wt-VAPB function and triggers PERK pathway, resulting in upregulation of cytotoxic transcription factor CHOP.
|
