2009 Fiscal Year Final Research Report
Proteomics Research about tumor promotion activity of polycyclic aromatic compounds
| Project/Area Number |
20890217
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Juntendo University |
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Principal Investigator |
MISAKI Kentaro Juntendo University, 大学院・医学研究科, 博士研究員 (40468591)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 発ガンプロモーション活性 / 多環芳香族化合物類 / プロテオミクス / シグナル伝達 / 遺伝子 / 環境 / 衛生 |
|---|
| Research Abstract |
Benzo[k]fluoranthene (B[k]FA), benzo[b]fluoranthene (B[b]FA) and benzopyrenone (BPO) showed significantly high promoting activity among 20 polycyclic aromatic compounds. It is suggested that AhR and reactive oxygen species (ROS) contribute to this activity for B[b]FA and B[k]FA, and ROS for BPO. In microarray analysis for B[k]FA, the increase of AhR-related mRNA and the change of several mRNAs were found. It is scheduled to identify proteins associated with promotion activity and elucidate the activity mechanism for these compounds.
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Research Products
(2 results)
