2009 Fiscal Year Final Research Report
Analysis of microsomal prostaglandin E synthase (mPGES-1) in chemical carcinogen-induced colon carcinogenesis
| Project/Area Number |
20890220
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
KAMEI Daisuke Showa University, 薬学部, 助教 (80515651)
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| Project Period (FY) |
2008 – 2009
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| Keywords | PGE合成酵素 / mPGES-1 / 発がん / 遺伝子欠損マウス / PGE2 |
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| Research Abstract |
We aimed at the possibility of microsomal prostaglandin E synthase-1 (mPGES-1), which was last synthase of PGE_2, as new therapeutic target of cancer. In this study, using various mPGES-1 gene modification mice, we analyzed the azoxymethane-induced colon tumorigenesis model. As a result, it was found that mPGES-1 contributed to initiation, promotion and progression of colorectal cancer as an exacerbation factor. This study suggested the possibility that inhibition of mPGES-1 was useful as an anticancer therapy of new mechanism of action.
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[Journal Article] Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.2009
Author(s)
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I.
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Journal Title
Biochem J. 425
Pages: 361-71
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[Journal Article] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.2008
Author(s)
Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H.
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Journal Title
Arthritis Rheum. 58
Pages: 172-83
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