2009 Fiscal Year Final Research Report
Analyses of cell fate determination in fetal hepatoblast
| Project/Area Number |
20890229
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
OIKAWA Tsunekazu Jikei University School of Medicine, 医学部, 助教 (20514491)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 幹細胞 / 再生医療 / 分化 |
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| Research Abstract |
Fetal hepatoblasts differentiate into both hepatocytes and cholangiocytes. The precise molecular mechanisms regulating this lineage commitment remain unknown. Sall4 has been shown to be among the regulators of embryogenesis, organogenesis, maintenance of pluripotency, and early embryonic cell fate determinations in ES cells. We here provide their first description in hepatoblasts. Sall4 plays a key role in regulating the lineage segmentation of hepatoblasts, not only inhibiting their differentiation into hepatocytes, but also driving their differentiation toward cholangiocytes.
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[Presentation] Sall4 Regulates Cell Fate Decision in Fetal Hepatoblasts.2008
Author(s)
Tsunekazu Oikawa, Akihide Kamiya, Sei Kakinuma, Mikio Zeniya, Ryuichi Nishinakamura, Hiromitsu Nakauchi, Hisao Tajiri
Organizer
The 59th Annual Meeting of the American Association for Study of the Liver Diseases, Moscone West Convention Center
Place of Presentation
San Francisco, CA, U.S.A
Year and Date
20081031-20081104
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