2009 Fiscal Year Final Research Report
Mechanisms of regulation of noradrenaline and dopamine efflux in the nucleus accumbens
| Project/Area Number |
20890236
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
AONO Yuri Nihon University, 歯学部, ポストドクター (50508497)
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| Project Period (FY) |
2008 – 2009
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| Keywords | カテコラミン / 大脳基底核 / 口腔ジスキネジア / 麻薬性鎮痛薬 / 鎮痛補助薬 |
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| Research Abstract |
Oral dyskinesia is a neurological syndrome which is characterized by the repetitive stereotyped oral movement. The detailed biological basis of the disorder remains unclear, but the behavioural studies suggest that the accumbal dopaminergic neurons play a pivotal role for the induction of repetitive jaw movements of rats. It is known that there exists a close noradrenaline-dopamine interaction within this nucleus. Therefore, in the present study, we investigated the mechanisms of the regulation of accumbal dopaminergic and noradrenergic activity in freely moving rats, using the in vivo brain microdialysis technique.
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