2009 Fiscal Year Final Research Report
The pharmacodynamic analysis of immunosuppressive agents using T-cell proliferation assay
| Project/Area Number |
20890250
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
KURATA Yoko Kinjo Gakuin University, 薬学部, 助教 (80513928)
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| Project Period (FY) |
2008 – 2009
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| Keywords | テーラーメイド / 免疫抑制薬 / 薬力学的解析 / Tリンパ球 |
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| Research Abstract |
The impact of pretransplant T-cell sensitivity testing using carboxylfluorescein diacetate succinimidyl ester (CFSE)-based flow cytometry was studied in 32 patients with chronic renal failure. There was considerable interindividual variation in the inhibitory effects of cyclosporine (CSA), tacrolimus (TAC), and prednisolone (PRD) but only a small amount of interindividual variation for mycophenolic acid (MPA). Patients with high sensitivity to CSA tended to experience viral reactivation. In addition to post-transplant blood-level monitoring, pretransplant pharmacodynamics could provide useful information on optimal and safe immunosuppressive therapy.
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[Journal Article] Pretransplant pharmacodynamic analysis of immunosuppressive agents using CFSE-based T-cell proliferation assay.2009
Author(s)
Kurata Y, Kato M, Kuzuya T, Miwa Y, Iwasaki K, Haneda M, Amioka K, Watarai Y, Uchida K, Nakao A, Kobayashi T
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Journal Title
Clinical Pharmacology&Therapeutics 86(3)
Pages: 285-289
Peer Reviewed
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[Presentation] 免疫抑制薬の薬力学的モニタリング法の確立2009
Author(s)
倉田洋子, 加藤真梨奈, 葛谷孝文, 野田幸裕, 羽根田正隆, 長坂隆治, 中尾昭公, 打田和治, 片山昭男, 小林孝彰, 網岡克雄
Organizer
第25回日本TDM学会・学術大会
Place of Presentation
東京
Year and Date
2009-06-22
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[Presentation] リアルタイムRT-PCRを用いた免疫抑制薬の薬力学的モニタリング2009
Author(s)
加藤真梨奈, 倉田洋子, 葛谷孝文, 野田幸裕, 羽根田正隆, 長坂隆治, 中尾昭公, 打田和治, 片山昭男, 網岡克雄, 小林孝彰
Organizer
第25回日本TDM学会・学術大会
Place of Presentation
東京
Year and Date
2009-06-22
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[Presentation] 移植におけるFoxp3発現の変化2008
Author(s)
岩瀬勇人, 小林孝彰, 中尾昭公, 片山昭男, 三輪祐子, 丹羽操, 岩崎研太, 羽根田正隆, 葛谷孝文, 櫛原秀之, 倉田洋子, 加藤真梨奈, 水谷加代子, 打田和治, 長坂隆冶
Organizer
第44回日本移植学会
Place of Presentation
大阪
Year and Date
2008-09-21
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