2009 Fiscal Year Final Research Report
The role of DNA damage by reactive nitrogen species in carcinogenic process caused by oncogenic K-ras mutation.
Project/Area Number |
20890254
|
Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Hygiene
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Research Institution | Suzuka University of Medical Science |
Principal Investigator |
OHNISHI Shiho Suzuka University of Medical Science, 薬学部, 助手 (80511914)
|
Project Period (FY) |
2008 – 2009
|
Keywords | DNA損傷 / 発がん機構 / ras遺伝子 / 8-ニトログアニン / バイオマーカー |
Research Abstract |
K-ras mutations are frequently observed in human lung cancer. On the other hand, it is considered that carcinogenesis consists from multi-step process with mutations in more than 10 genes. In this study, 8-nitroguanine and 8-oxodG was apparently formed in lung adenocarcinoma caused by oncogenic K-ras, withoutinflammation. It is reported that 8-nitroguanine and 8-oxodG can cause mutations. These suggest that the accumulation of mutagenic 8-nitroguanine and 8-oxodG contributes to promotion of lung carcinogenesis initiated by K-ras mutation.
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Research Products
(9 results)