2009 Fiscal Year Final Research Report
Immune regulatory effect of C-type lectin DC-SIGN on colorectal tumors
| Project/Area Number |
20890255
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
NONAKA Motohiro Ritsumeikan University, 総合理工学研究機構, 研究員 (70514173)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 樹状細胞 / 結腸がん / 免疫制御 |
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| Research Abstract |
We found that C-type lectin DC-SIGN expressed on dendritic cells recognized colorectal tumor-associated Lewis glycans expressed on colorectal carcinoma COLO205 cells, which contributed to tolerogenic immunity for tumor cells. We identified DC-SIGN ligands which were involved in the interaction with DC-SIGN. Moreover, we revealed that mannan binding protein interacted with DNA derived from various orignins in a calcium dependent manner.
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