2009 Fiscal Year Final Research Report
Expression regulation and synthetic pathway of SIGIRR/TIR8, a negative regulator of Toll like receptor signaling
| Project/Area Number |
20890276
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
SHUTO Keiko Sojo University, 薬学部, 助手 (70510692)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 炎症制御 |
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| Research Abstract |
SIGIRR/TIR8 has been reported to negatively regulate Toll-like receptor (TLR) signaling, that plays critical role for inflammatory response. However, precise mechanism responsible for the regulation of SIGIRR expression during TLR signaling remains obscure. In this study, we confirmed the regulation of SIGIRR expression by Lipopolysaccharide (LPS), which is well known as a TLR activator. As a result, LPS down regulated SIGIRR expression at transcriptional level. Moreover, p38 MAP kinase downstream of TLR signaling, and transcriptional factor Sp1 were possibly involved in LPS induced SIGIRR down-regulation.
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