2021 Fiscal Year Annual Research Report
ユビキタス海洋動物プランクトン、ワカレオタマボヤの集団ゲノム科学
| Project/Area Number |
20F20760
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
ラスカム ニコラス 沖縄科学技術大学院大学, ゲノム・遺伝子制御システム科学ユニット, 教授 (70724087)
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| Co-Investigator(Kenkyū-buntansha) |
MANSFIELD MICHAEL 沖縄科学技術大学院大学, ゲノム・遺伝子制御システム科学ユニット, 外国人特別研究員
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| Project Period (FY) |
2020-09-25 – 2022-03-31
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| Keywords | genomics / bioinformatics / marine biology / zooplankton / Oikopleura / functional genomics / ecology / evolution |
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| Outline of Annual Research Achievements |
In FY2021, I contributed to two studies on genetic variation in O. dioica. The first reports that the species O. dioica may in fact be a species complex representing multiple lineages. The second demonstrates a considerable degree of genetic rearrangement in these species, which is unique among chordates and perhaps all metazoa.
We began follow-up studies to examine the effects of this rearrangement on gene expression, achieving two important milestones in FY2021. In FY2020, we established the ATACseq method. In FY2021 we completed sampling and sequencing for RNAseq and ATACseq in two O. dioica populations, across developmental time points. We also established the hybridization chain reaction in O. dioica to accurately observe the spatiotemporal patterns of expression in real time.
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| Research Progress Status |
令和3年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和3年度が最終年度であるため、記入しない。
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[Journal Article] Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold2022
Author(s)
Sugiman-Marangos, S. N., Gill, S. K., Mansfield, M. J., Orrell, K. E., Doxey, A. C., & Melnyk, R. A.
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Journal Title
Communications biology
Volume: 5(1)
Pages: 1-12
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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