2023 Fiscal Year Final Research Report
Understanding the configuration and dynamics of the brain network underlying emotion and social behavior
| Project/Area Number |
20H00104
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 10:Psychology and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北城 圭一 生理学研究所, システム脳科学研究領域, 教授 (70302601)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | サル / 神経トレーシング / ウイルスベクター / 電気生理学 / 多点電極 |
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| Outline of Final Research Achievements |
To clarify the mechanisms by which emotions and motivation arise in the brain, we performed neural circuit tracing, neural activity intervention, and multi-point simultaneous recording of neural activity (local field potentials). Neural circuit tracing revealed that the medial frontal cortex, in particular, has dense neural connections with the amygdala and nucleus accumbens. Neural activity intervention revealed that the ventral part of the medial frontal cortex is particularly involved in regulating emotions and mood. Multi-channel recording of neural activity suggested that information on emotions and motivation that modifies movement is sent from the medial frontal cortex to the movement-related cortices in the lateral frontal lobe.
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| Free Research Field |
生理心理学、システム神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
脳の中での情動や意欲の生成過程については、これまで不明な点が多かったが、本研究により、扁桃体・側坐核と、内側前頭皮質が重要な役割を担っていることが明らかになった。また、情動や気分が行動に影響を与えるのは、内側前頭皮質と外側の運動関連皮質の機能連関による者と示唆された。本研究の成果は、情動や意欲の神経機構の解明への足がかりとなるばかりでなく、うつ病やその他の精神疾患の病態の理解や治療法の改善・開発につながることが期待される。
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