2023 Fiscal Year Final Research Report

Creation of Novel N-Confused Metallo-porphyrinoid System

Research Project

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Project/Area Number	20H00406
Research Category	Grant-in-Aid for Scientific Research (A)
Allocation Type	Single-year Grants
Section	一般
Review Section	Medium-sized Section 37:Biomolecular chemistry and related fields
Research Institution	Ritsumeikan University (2022-2023) Kyushu University (2020-2021)
Principal Investigator	FURUTA HIROYUKI 立命館大学, 総合科学技術研究機構, 教授 (40244157)
Co-Investigator(Kenkyū-buntansha)	石田真敏東京都立大学, 理学研究科, 准教授 (60706951) 井川善也富山大学, 学術研究部理学系, 教授 (70281087) 清水宗治九州大学, 工学研究院, 准教授 (70431492)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	ポルフィリン異性体 / Nー混乱ポルフィリン / 金属錯体 / 近赤外色素
Outline of Final Research Achievements	Based on the N-confused porphyrinoid chemistry containing a confused(inverted) pyrrole ring, developed independently by us, we have synthesized various molecules capable of metal coordination and investigated their optical, electronic, and magnetic properties, aiming to create molecular materials that can exhibit a variety of functionalities (multi-electron transfer ability, catalytic ability, photothermal conversion ability, etc.). Among N-confused ring-contracted and ring-expanded porphyrinoids, we discovered many molecules that function in the low-energy optical window called the second near-infrared (NIR-II).
Free Research Field	機能有機分子化学
Academic Significance and Societal Importance of the Research Achievements	異種ポルフィリノイドとして新たなクラスを形成するN―混乱ポルフィリノイドの未知なる基本物性や反応性等を発見すると共に、深部固形がんの治療において注目されている「近赤外光免疫治療法」には欠かす事のできない近赤外光感受性薬剤分子への応用展開可能な、第二近赤外（NIR-II）低エネルギー光学窓で機能する化合物を多数見出すことに成功した。