2023 Fiscal Year Final Research Report
Analysis of Stress Gateway Reflex
| Project/Area Number |
20H00502
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 49:Pathology, infection/immunology, and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 勇希 北海道大学, 遺伝子病制御研究所, 助教 (50794020)
山崎 理絵 (長谷部理絵) 北海道大学, 遺伝子病制御研究所, 講師 (70431335)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | ゲートウェイ反射 |
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| Outline of Final Research Achievements |
We have discovered six gateway reflexes (G-reflexes) in which specific neural circuit activation triggered by environmental stimuli transforms specific blood vessels and induces tissue-specific inflammatory pathology, using autoimmune disease models that occur mainly in blood immune cells including autoreactive T cell-dependent manner. In this study, we will analyze how stress-related stimuli, including pain and inflammation, cooperate with autoreactive T cells in the blood to induce organ-specific inflammatory diseases, mainly using the stress G reflex and other G reflexes. In addition, we will also materialize a completely new and innovative methodology to prevent and treat stress-induced inflammatory diseases.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
主な論文成果を記載する。病態モデルにてストレス関連の痛みや局所炎症を起点とするゲートウェイ反射の解析が進み２論文を発表した（J Exp Med, 2022, J Immunol, 2023）。さらに、重症全身性エリテマトーデスに認められる精神神経ループス病態を反映するストレス依存性病態モデルを作成し、本分子機構が患者存在することを示唆（Ann Rheum Dis, 2022）でき、て脳内炎症が示唆されるてんかん患者にて迷走神経非侵襲刺激を実施し発作が減弱した（Brain Develop, 2023）。関連論文として28報の英文論文を発表した。大きな成果が得られ社会的な意義も大きい研究となった。
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