2023 Fiscal Year Final Research Report
Fluid dynamical study of inertial focusing phenomena for application to cell separation
| Project/Area Number |
20H02072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 19010:Fluid engineering-related
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| Research Institution | Kansai University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 慣性集束現象 / 変形性 / 粘弾性 |
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| Outline of Final Research Achievements |
Particles suspended in a laminar flow through a narrow channel are known to migrate toward specific positions in the channel cross-section due to the presence of the inertial lift force. As the focusing position and focusing distance of particles depend on their size, shape and deformability, this phenomenon can be applied to the separation of suspended cells using suitably designed microfluidic devices. As a basis for the design of microfluidic devices, this study investigated the inertial migration of particles flowing through straight channels experimentally and numerically, focusing on the effect of deformability of suspended particles and the viscoelastic property of the suspending fluid.
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| Free Research Field |
流体物理学
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| Academic Significance and Societal Importance of the Research Achievements |
細胞の混合液から特定の細胞を分離・検出する操作は，癌などの臨床診断を含む医学や生物学など広範囲な分野で不可欠となっている．現状は大掛かりな装置が必要であるのに対し，流れを利用した分離手法は小型で安価なマイクロ流体デバイスを用いるもので，細胞への負荷が小さいなど多くの利点を有することから，現在世界中で活発に研究が行われている．本研究では，有効なデバイス開発のための基礎研究として，細胞の特性である変形性や流体の粘弾性に着目して，流れ中の浮遊粒子の挙動を実験と数値解析により流体力学的観点から詳細に調べた．
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