Development of innovative antiviral materials and investigation of their activity mechanism for the safe and secure society

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H02432
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 26020:Inorganic materials and properties-related
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Nakajima Akira 東京工業大学, 物質理工学院, 教授 (00302795)
• Co-Investigator(Kenkyū-buntansha): 砂田 香矢乃 地方独立行政法人神奈川県立産業技術総合研究所, 光触媒グループ, 研究員(任期有) (20311433) ; 磯部 敏宏 東京工業大学, 物質理工学院, 准教授 (20518287)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: ウイルス / 酸化物 / 希土類 / 菌 / バクテリオファージ

Outline of Final Research Achievements

A sample in which La of La2Mo2O9 (LMO) was replaced with Ce (Ce2Mo3O13) exhibited a high antiviral activity against the novel coronavirus. A method for preparation of porous transparent thin films of LMO was developed. It was revealed that a composite oxide of Cu and Mo (CuMoO4) exhibited antibacterial, antiviral, and antifungal activities simultaneously. We demonstrated that CeO2 doped with La ((Ce0.8La0.2)O2-d) exhibited antiviral activity. Both LaMnO3 and LaCoO3 were shown to be antibacterial and antiviral materials with low elution amounts. SnO2-MoO2 solid solution ((Sn0.5,Mo0.5)O2) possessed a high activity against viruses and fungi. Regression analysis using the obtained experimental results revealed that specific ions have a strong effect on bacteria and non-enveloped viruses, which is different from the effect on viruses with hydrophobic envelopes.

Free Research Field

無機材料科学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、申請者らが発見したモリブデン酸複合酸化物群という材料をプラットホームにして無機材料分野の研究者とウイルス関連分野の研究者が互いに協力・補完しあうことで、無機材料科学とウイルス関連分野の境界への新たな知見を付与したことである。本研究の成果はウイルス対策における新たな知見を与え、ワクチンだけに頼らない、人類がウイルスに対する新たな盾を手にするという点において、社会的意義も高い。さらに、近年わが国で頻発する大規模自然災害等の被災地での衛生環境確保の面においても、本研究の成果は有効な材料技術を与えることになる。