2022 Fiscal Year Final Research Report
Three-dimensional cutlure for hari regenerative medicine
Project/Area Number |
20H02535
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 27040:Biofunction and bioprocess engineering-related
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Research Institution | Yokohama National University |
Principal Investigator |
Fukuda Junji 横浜国立大学, 大学院工学研究院, 教授 (80431675)
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Co-Investigator(Kenkyū-buntansha) |
景山 達斗 地方独立行政法人神奈川県立産業技術総合研究所, 「再生毛髪の大量調整革新技術開発」プロジェクト, 研究員(任期有) (40822177)
大久保 佑亮 国立医薬品食品衛生研究所, 毒性部, 主任研究官 (80596247)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 毛髪の再生医療 / 毛包上皮幹細胞 / 毛乳頭細胞 / バイオプリンター |
Outline of Final Research Achievements |
In this study, we have investigated on three approaches: (1) technology for proliferation of hair follicle epithelial stem cells in 3D culture, (2) technology for proliferation of dermal papilla cells by electrically stimulated culture, and (3) technology for generation of hair follicle germs using a bioprinter, for hair regenerative medicine. For (1), a patent application is in preparation, but a possible approach has been identified. For (2), we have published a paper and elucidated the activation mechanism via voltage-dependent ion channels. For (3). we have also published a paper and established a bioprinter technology capable of producing several thousand hair follicle germs. In summary, the fundamental technologies for hair regenerative medicine has been established.
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Free Research Field |
生物工学
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Academic Significance and Societal Importance of the Research Achievements |
毛包を構成する細胞の性質やその組織化のメカニズムを理解するとともに、これに基づき毛髪を再生する技術の確立に取り組んだ。これにより毛髪の再生医療が実現できる可能性があり、男性型脱毛症を含む毛髪関連疾患の新しい治療法となりうる可能性がある。実際、毛髪再生医療の実用化に向けて、安全性試験などを含めた検討にも取り組んでいる。
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