Investigation of nanomaterial design for preferential tumor accumulation

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H02584
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 28040:Nanobioscience-related
• Research Institution: Kyoto University
• Principal Investigator: Komatsu Naoki 京都大学, 人間・環境学研究科, 教授 (30253008)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: ナノ粒子 / ポリグリセロール / 癌 / 腫瘍

Outline of Final Research Achievements

First, protein corona formation was examined for nanodiamond (ND) and magnetic iron oxide nanoparticles (SPION) coated with polyglycerol (PG) and further modified with various functional groups such as carboxy groups, amino groups, sulfonate, and phosphonium. The results showed that negatively charged groups such as carboxy one did not produce protein corona, while positively charged amino groups produced protein corona. The cellular uptake is found to be facilitated proportionally by the amount of corona proteins. Therefore, it is important to control the formation of protein corona by using negatively charged functional groups for tumor-selective accumulation of polyglycerol-functionalized nanoparticles.

Free Research Field

ナノ材料化学

Academic Significance and Societal Importance of the Research Achievements

ポリグリセロール修飾ナノ粒子の腫瘍選択的集積の原因が明らかになれば、それがナノ製剤の新たな設計指針となり、ナノ医療の分野にパラダイムシフトを起こすことが可能である。一方。この研究成果は、癌の早期発見や治療にも繋がり、社会的にも経済的にも大きなインパクトがあると考えている。