Rational Design of Acid-Base Cooperative Chiral Supramolecular Catalysts to Control Multiselective Reactions

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H02735
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: Hatano Manabu 神戸薬科大学, 薬学部, 教授 (20362270)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 有機合成化学 / 不斉触媒反応 / マルチ選択性 / 酸・塩基複合化学 / 超分子触媒

Outline of Final Research Achievements

Reactions proven by diverse enzymes are some of the most efficient molecular-controlling technologies. In order to control multiselectivity in fine organic synthesis, we have to develop new artificial enzymes to overcome the limit of the design of the conventional catalysts. In this research, based on acid-base cooperative chemistry, we precisely designed the small molecules of the key catalysts, flexibly connected these molecules by using the inherent attractive interactions between acids and bases, and consequently developed activated designers supramolecular catalysts in situ. By creating a chiral cavity corresponding to the enzyme-like keyhole and active site, we developed unique molecular formation reactions and multiselective reaction controls that could not be realized by conventional catalysts.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

ナノスケールの触媒を効率的に創製するための有力な手段となる酸・塩基複合化学は、酸と塩基の融合領域を開拓するものであり、酸または塩基単一では成し得ない優れた特長が現れる。これを土台として、特に本研究では、合成化学・触媒化学・超分子化学を横断する酸・塩基複合化学に立脚した独創的なナノスケールの触媒設計を行い、従来の単一分子触媒では制御が困難なマルチ選択的触媒反応を実現した。これは、次世代の有機合成化学が目指す技術革新の一歩として意義付けられ、将来の有機合成化学が本格的に到達するであろう酵素機能に迫る機能を持った精密人工触媒の礎を築くものである。