Transfer (de)hydration for organic synthesis

2023 Fiscal Year Final Research Report

• Project/Area Number: 20H02736
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Kyoto University
• Principal Investigator: Naka Hiroshi 京都大学, 薬学研究科, 准教授 (70431517)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 水移動型反応 / 水和反応 / 脱水反応 / 触媒 / 有機化学 / 合成化学 / ニトリル / アミド

Outline of Final Research Achievements

This study explored transfer hydration catalysis, which formally hydrates unsaturated organic compounds using water donors, and investigated its potential in organic synthesis. As a result, four catalytic reactions were developed: palladium-catalyzed transfer hydration of aminonitriles, platinum-catalyzed transfer hydration of nitriles, ruthenium-catalyzed transfer dehydration of amides, and iridium-catalyzed transfer dehydration of amides.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究で実施した水移動型触媒反応の開発と反応機構の解明は、合成化学の水準を高め、分子触媒の設計に新たな指針を与えるものである。また、優れた合成プロセスの創出は、医薬品や農薬をはじめとする新素材の開発や製造にかかわる効率化をもたらすことが期待できる。