2023 Fiscal Year Final Research Report
Carbon-Hydrogen bond activation reactions realized by long-range steric effect of ligands
| Project/Area Number |
20H02738
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 33020:Synthetic organic chemistry-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 炭素－水素結合 / パラジウム / ロジウム |
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| Outline of Final Research Achievements |
In this study, we investigated the steric effects of bulky carboxylato ligands on transition-metal catalyzed reactions. In the intermolecular carbon-hydrogen bond arylation reaction using palladium catalysts, the desired reactions proceeded under mild reaction conditions when using carboxylato ligands with appropriate bulkiness. In the carbene insertion reaction using dinuclear rhodium complexes with a carboxylato ligand, the catalyst with a bulky peripheral ligand showed different chemoselectivity as compared to the catalyst with a normal carboxylato ligand.
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| Free Research Field |
有機合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
今回，カルボキシラト配位子の立体に着目した研究を進め，配位部位から離れた遠隔位のかさ高さが触媒反応の効率や化学選択性を制御できることが分かった。これらの成果は我々独自の考え方に基づくものであり，学術的な意義は高い。今後，医薬品や農薬の合成中間体の合成を志向した反応開発へと展開し，産業界への貢献を目指す。
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