2023 Fiscal Year Final Research Report
Development of multi-electron reduction reactions of oxoanions on metal complexes
| Project/Area Number |
20H02757
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 34010:Inorganic/coordination chemistry-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 亜硫酸イオン / 還元活性化 / 多電子還元 / 硫黄酸化物 / 金属酵素 / 二核錯体 / ピラゾリルボラト / ルテニウム |
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| Outline of Final Research Achievements |
Sulfite reduction by dissimilatory sulfite reductases is a key process in the global sulfur cycle. Sulfite reductases catalyze the 6e－ reduction of SO32－ to H2S using eight protons. However, detailed research into the reductive conversion of sulfite on transition-metal-based complexes remains unexplored. As part of our ongoing research into reproducing the function of reductases using dinuclear ruthenium complex, we have targeted the function of sulfite reductase. The isolation of a key SO-bridged complex, followed by a sulfite-bridged complex, eventually resulted in a stepwise sulfite reduction. The reduction of a sulfite to a sulfur monoxide using 4H+ and 4e－, which was followed by conversion of the sulfur monoxide to a disulfide with concomitant consumption of 2H+ and 2e－, proceeded on the same platform. Finally, the production of H2S from the disulfide-bridged complex was achieved.
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| Free Research Field |
錯体化学
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| Academic Significance and Societal Importance of the Research Achievements |
地球上では、硫黄循環サイクルが存在し、硫黄は生命活動にとって重要な元素である。生物による硫黄の循環で重要なのは、硫酸還元細菌が行う硫酸イオンの異化的還元によるスルフィドの生成である。生物は、硫酸イオンを亜硫酸イオンに還元し、さらに亜硫酸イオンを還元してスルフィドを得るという２段階で硫酸イオンを還元している。特に２段階目の亜硫酸イオンからスルフィドへの変換は、異化型亜硫酸還元酵素と呼ばれる酵素によって行われている。この反応を、人工的に金属錯体を使って再現した。
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