2022 Fiscal Year Final Research Report
Electrochemical measurement for the elucidation of principle of spatial coupling of charge transport reactions mimicking biological membrane reactions
| Project/Area Number |
20H02765
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
Maeda Kohji 京都工芸繊維大学, 分子化学系, 教授 (00229303)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | エネルギー変換 / 電荷移動共役 / ボルタンメトリー / 電位振動 / 同期 / 界面伝播 / ペースメーカー |
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| Outline of Final Research Achievements |
Regarding coupling reactions between ion and electron transport at spatially separated sites, the following results were demonstrated; the unique phenomenon that additives other than at the rate-determining interface dominate the coupling rate, the possibility of breaking the electrical neutrality in the order of milliseconds during the initial coupling process, the enhancement of the coupling rate by proximity between coupling sites, and the unique role of a third ion transport site that mediates the coupling rate.
Regarding propagation and synchronization between multiple potential oscillation systems, the chemical species propagating on the interface were investigated through the use of fluorescent ions. As for the propagation between three or more oscillation systems, we found a pattern in which one autonomic pulse propagates to other oscillation systems as a passive pulse and another pattern in which autonomic pulses propagate sequentially.
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| Free Research Field |
電気分析化学
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| Academic Significance and Societal Importance of the Research Achievements |
ミトコンドリアにおけるプロトン共役説の原理や共役の特異性をモデル化したことにより、ミトコンドリア病などエネルギー変換機能の不調や、外部からの薬物注入によるエネルギー変換機能の麻痺などの原因の追究に寄与することができる。また、複数の振動系の同期と伝播のモデルは、心臓や膵臓の正常と異常の差異の原因を示した。すなわち、電気的伝播と物質的伝播の両方が存在することやペースメーカーの有無に依存することに留意することを示唆する。後者については、多数の刺激細胞の中にペースメーカーが存在する場合は安定な同期状態をもたらし、逆に、ペースメーカーが存在しないと、同期パターンが多岐にわたり不整脈的パターンをもたらす。
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