2022 Fiscal Year Final Research Report
Development of highly-concentrated dye liquid nanoparticles and their application to highly-sensitive chemical sensing devices
| Project/Area Number |
20H02770
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | Osaka Metropolitan University (2022)
Osaka Prefecture University (2020-2021) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | イオン液体 / 色素液体 / ナノ粒子 / マイクロ分析デバイス |
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| Outline of Final Research Achievements |
In this research, various dye liquids were developed, made into thin films and nanoparticles, and response performance evaluations for various analytes were performed. In addition, we have developed various microanalytical devices using them. As a result, high-speed response to heparin, which had been forced to take a long response time, ultra-high-sensitivity detection based on energy transfer between the donor and acceptor utilizing the characteristics of fluorescent dye liquids, elucidation of the anion response mechanism, fast and high-sensitivity response to enzymes, high-speed response of cations accompanying nanoparticle formation, etc. have been realized. In the development of devices using inkjet technology, in addition to the detection of substances such as CRP and anions, which were originally intended, applications to new one-step evaluation systems such as application to enzyme inhibitor assay systems were also demonstrated.
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| Free Research Field |
分析化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、従来固体粉末であることが常識だった色素の液状化で、色素を用いる化学センシングに新たな方法論を多数生み出した点で学術的意義は極めて大きい。また、マイクロ分析デバイス化でもインクジェット技術の利用や試薬固定化の方法論開発、溶解プロセスの詳細検討など、実用的にも重要となる知見を多数生み出した。これらの知見は現在の診断デバイスの改良や、新たなデバイス開発の基礎となる知見であるため、社会的意義も極めて大きいと考える。
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