2022 Fiscal Year Final Research Report
Preparation of mechanobiological polymer gels by independent control of mechanical/chemical properties
Project/Area Number |
20H02804
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 35020:Polymer materials-related
|
Research Institution | National Institute for Materials Science |
Principal Investigator |
UEKI Takeshi 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主任研究員 (00557415)
|
Co-Investigator(Kenkyū-buntansha) |
中西 淳 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (60360608)
|
Project Period (FY) |
2020-04-01 – 2023-03-31
|
Keywords | 高分子ゲル / イオン液体 / イオンゲル / ブロック共重合体 / メカノバイオロジー / 細胞足場材料 |
Outline of Final Research Achievements |
In the research field of mechanobiology, which explores the effects of "force" on biological phenomena, it is desirable to establish a functional polymer gels that allows independent control of the mechanical and chemical properties of materials. In this study, we aimed at realizing polymer gel scaffold using ionic liquids (ILs) as solvents, whose liquid properties can be easily controlled. The main results of this study are as follows: (1) radical polymerization in ILs can form ion gels based on unique polymer entanglement as a dynamic cross-linking point, (2) the mechanical/chemical properties of ion gels can be controlled by changes in ILs and polymer structures, and (3) cell scaffold materials consisting of azobenzene-bearing polymer gels have been prepared to investigate the response to mechanical stress. The response of MCF-7 cells against mechanical stimuli was investigated and reported.
|
Free Research Field |
高分子材料
|
Academic Significance and Societal Importance of the Research Achievements |
細胞は生理化学的要因のみならず力学的要因によっても、その動態や運命を決定することが知られている。本研究により、力学操作のみによって生命現象を制御できるような医療技術が開発されれば、既存の薬物による治療法から脱却した画期的治療法「メカノセラピー」が可能になり次世代の健康社会創出(医療費の抑制、健康寿命の延伸、社会活動時間の増加、介護負担・費用の低減など)に貢献することができる。
|