Improvement of the accuracy of transient circular dichroism measurements for the detection of the chirality of transient molecules

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H02806
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 35030:Organic functional materials-related
• Research Institution: Tohoku University
• Principal Investigator: ARAKI YASUYUKI 東北大学, 多元物質科学研究所, 准教授 (80361179)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 円二色性 / キラリティ / 電子励起状態

Outline of Final Research Achievements

Since there are very few examples of circular dichroism spectra in the photo-excited state, it is important to observe and interpret them from an academic point of view. In addition, the development of EL devices that directly emit circularly polarized light is expected to benefit from the knowledge of the chirality of the photo-excited state obtained from the spectral analysis.The authors have developed a transient circular dichroism measurement method. We have succeeded in measuring the transient circular dichroism spectra of helicene in the photo-excited triplet state.We believe that by establishing a simpler and more accurate method for measuring transient circular dichroism spectra, this method will contribute to the development of science.
Therefore, in this study, we have improved the measurement apparatus we have developed so far and performed transient circular dichroism measurements with it.

Free Research Field

光化学

Academic Significance and Societal Importance of the Research Achievements

円二色性スペクトルは、タンパク質や核酸などの生体分子のような光学活性な化合物の構造を簡便に理解するために有用です。しかしながら、これらのスペクトルから得られる構造情報は基本的に静的なものであり、溶液中でダイナミックに構造を変える生体分子の挙動を追うことはごく限られた研究でしか行えていませんでした。本研究ではそれを踏まえ、円二色性測定法を改良したとえばスナップショットを取るように動的に動く分子の円二色スペクトル測定を行う手法を開発することを目的とし、その基礎的な測定手法の確立と改良を行いました。この測定手法は、将来生体分子と薬剤との相互作用等の理解のために有用であると考えられます。