New antibiotics development

2023 Fiscal Year Final Research Report

• Project/Area Number: 20H02878
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 37030:Chemical biology-related
• Research Institution: Kyoto University
• Principal Investigator: KIM MINSOO 京都大学, 医学研究科, 准教授 (50466835)
• Co-Investigator(Kenkyū-buntansha): 山吉 麻子 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (70380532) ; 水島 恒裕 兵庫県立大学, 理学研究科, 教授 (90362269)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 病原細菌 / ケミカルバイオロジー

Outline of Final Research Achievements

There is an unmet medical need for the development of new anti-microbial drugs of bacterial infections that act by a different mechanism of action than existing antibiotics, are effective against multidrug-resistant bacteria, are effective only against pathogenic bacteria, and do not act on commensal bacteria or the host. In this study, we aimed to develop a new concept anti-microbial drug of infectious diseases that is different from existing antibiotics, does not affect commensal bacteria, and is specific to the virulence of pathogenic bacteria. Specifically, we aimed to create “compounds that inhibit the virulence of bacterial virulence factors” and establish for the new therapeutic tools of bacterial infections by inhibiting the function of virulence factors.

Free Research Field

感染生物学

Academic Significance and Societal Importance of the Research Achievements

薬剤耐性菌による感染症は、生命を脅かす危険性があり、アンメット・メディカル・ニーズは極めて高い。本研究で開発される新しい概念の感染症治療薬は、新興・再興感染症に対するグローバルな感染症対策に対して更なる貢献が期待できる。学術的には、遺伝子操作が不可能な病原細菌に対して、本化合物は、病原蛋白質をノックアウトするツールとして利用可能で、病原因子の感染に果たす分子メカニズム解明に貢献すると考えらえる。