2023 Fiscal Year Final Research Report
Study on the saliva-assisted pathogen transmission mechanism in the tick vector
| Project/Area Number |
20H03001
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 39050:Insect science-related
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
田仲 哲也 鹿児島大学, 農水産獣医学域獣医学系, 教授 (00322842)
藤田 修 国立感染症研究所, 獣医科学部, 主任研究官 (20260276)
|
|---|
| Project Period (FY) |
2020-04-01 – 2024-03-31
|
| Keywords | フタトゲチマダニ / マダニ媒介感染症 / SAT / ワクチン / 唾液腺 / RNAi / 免疫抑制 / 血管新生 |
|---|
| Outline of Final Research Achievements |
Current tick control methods have limitations in preventing tick-borne diseases (TBDs). This research explores a novel approach: an "anti-salivary vaccine." This vaccine targets specific molecules in tick saliva that aid pathogen transmission. By analyzing the genes expressed in tick salivary glands during feeding, we identified two new genes, HLCBP1 and HLHBP1. These genes are only active when the tick is feeding and play a crucial role in its blood-sucking efficiency, as well as manipulating the host's immune response and blood vessel growth. These findings pave the way for the development of innovative tick vaccines that target these salivary molecules. Unlike traditional insecticides, this sustainable technology has the potential to significantly advance the fight against TBDs.
|
| Free Research Field |
分子寄生虫学
|
| Academic Significance and Societal Importance of the Research Achievements |
地球温暖化を背景としたマダニの棲息域の拡大は、マダニ媒介感染症の拡大にも寄与することから、これらの防除は地球規模での解決を求められている。本研究により世界に先駆けて見出すことに成功したフタトゲチマダニ唾液遺伝子HLCBP1とHLHBP1は、マダニの吸血にとって必須の分子である。このような分子を標的としたワクチンの開発は、マダニのみならずマダニ媒介感染症の効果的な制御に資するものであり、化学的防除法に頼らない新たな施策は持続可能な社会の形成にも貢献する技術となる。
|
