Molecular Basis and Physiological Functions of Diverse Selective Autophagy

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H03213
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 43030:Functional biochemistry-related
• Research Institution: Juntendo University
• Principal Investigator: Morishita Hideaki 順天堂大学, 医学部, 准教授 (90783499)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: オートファジー / リソソーム / 恒常性維持

Outline of Final Research Achievements

Autophagy can efficiently remove specific intracellular components. This action, called selective autophagy, has recently been suggested to be involved in suppression of various diseases, but what substrates are degraded by selective autophagy in vivo, and by what molecular mechanism, has been largely unknown. In this study, we established a new selective autophagy inhibition method and comprehensively identified the substrates of selective autophagy in vivo. In the future, this technique will lead to a comprehensive understanding of intracellular degradation under physiological and pathophysiological conditions.

Free Research Field

細胞生物学、分子生物学、生化学

Academic Significance and Societal Importance of the Research Achievements

近年、選択的オートファジーの破綻は神経変性疾患（パーキンソン病、萎縮性側索硬化症、前頭側頭型認知症、βプロペラ蛋白関連神経変性症、Vici症候群等）、腫瘍、感染症等の様々な疾患と関連することが示唆されている。本研究では生体内での選択的オートファジーの役割を基質レベルで解析するツールを開発できたため、今後、本ツールを各種ストレス下や疾患モデルでの解析に適用していくことで、選択的オートファジー不全疾患の病態の解明や、予防・治療法のシーズ同定つなげていくことができる。