The mechanism of H3K9 demethylation at the Sry locus

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H03262
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 44020:Developmental biology-related
• Research Institution: Osaka University
• Principal Investigator: Kuroki Shunsuke 大阪大学, 大学院生命機能研究科, 准教授 (50735793)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 性決定

Outline of Final Research Achievements

Sex determination and sex differentiation are the most important events in the survival of a species, and many transcription factors involved in sex determination have been identified, including the sex determination gene Sry on the Y chromosome. On the other hand, how the epigenome is involved in sex determination is still poorly understood. In this study, we searched for proteins that bind to Jmjd1a to elucidate the mechanism by which Jmjd1a, a histone H3K9 demethylase, targets the Sry locus. As a result, we identified a novel Zn finger protein as a candidate.

Free Research Field

発生生物学

Academic Significance and Societal Importance of the Research Achievements

ヒトの性分化疾患（DSD, Disorders of Sex Development）は性の決定・分化が正しく進行しない場合に発症する病気である。DSDの半数以上の症例でその原因は未だ不明である。本研究によって同定した新規因子と性決定の関わりを明らかにすることで、DSD発症の新たな原因解明に繋がることが期待される。