2022 Fiscal Year Final Research Report
Study on cell cycle regulation in meiosis I
| Project/Area Number |
20H03265
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 44020:Developmental biology-related
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | 減数分裂 / 体細胞分裂 / 生殖細胞 |
|---|
| Outline of Final Research Achievements |
The purpose of this study is to elucidate the cell cycle regulatory mechanisms of meiotic first division. Based on analysis of the target genes of the meiosis initiation factor MEIOSIN, we identified novel regulators of meiosis. We also found that there are sexual differences in the regulation of meiosis initiation and that the interaction between retinoblastoma Rb and STRA8 acts in the regulationin females .
|
| Free Research Field |
発生生物学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究で見いだされた新規の減数分裂関連遺伝子の発見は、不妊の原因解明に資することが期待される。また、減数分裂の開始の制御には雌雄性差があることや、特にメスの減数分裂の開始には癌抑制遺伝子レチノブラストーマによる制御があることが判明して、卵子発生におけるメカニズムの理解が進んだ。
|
