Synthesis and catalytic reaction of novel metal complexes containing Z-type ligands aiming at unusually high oxidation numbers

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H03370
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
• Research Institution: Kobe Gakuin University
• Principal Investigator: Inagaki Fuyuhiko 神戸学院大学, 薬学部, 教授 (80506816)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: Z型配位子 / 塩化銅 / 塩化金 / 触媒 / 環化反応 / 分子間反応

Outline of Final Research Achievements

Synthesis of Au(DPB)Cl3 with (Au→B)8-type electron configuration, and application of Au(DPB)(SbF6)3 catalyst prepared from this gold complex and AgSbF6 to the cyclization reaction with in-indole substrates was investigated. As a result, it was found that a product having a 7/5/7-membered tricyclic structure containing a spiro structure was obtained. In addition, we attempted to synthesize a copper catalyst Cu(DPB)Cl3 with Z-type ligands. Although we did not obtain the desired complexes, we newly found [(PBP)CuCl3]2 with cation-rich canter ions. The synthsized complex was useful for the catalyst of Mukaiyama-Aldol reaction between a ketene silyl acetal substrate and a ketone substrate.

Free Research Field

有機化学

Academic Significance and Societal Importance of the Research Achievements

本成果は、従来合成不可能とされてきた異常抗酸化数を有する金属錯体の合成に一石投じるものとなるばかりでなく、その触媒反応が新たな反応性を提供する有効性をも提供するに至った。今後、X線結晶構造解析による異常抗酸化数の証明や簡便合成法の確立、触媒反応による新規反応性創出といった展開が可能であり、学術的意義は大きい。また、従来困難な触媒反応開発への展開可能性も有し、大きな社会的意義も秘めている。