2022 Fiscal Year Final Research Report
Basis of treatment strategy for type 2 diabetes using new indices obtained by visualization of pancreatic beta cell activities in vivo
| Project/Area Number |
20H03430
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 48030:Pharmacology-related
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
金丸 和典 日本大学, 医学部, 准教授 (10456105)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | カルシウム / 膵β細胞 / インスリン / イメージング |
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| Outline of Final Research Achievements |
Insulin is secreted from pancreatic β cells as the only hormone that lowers blood glucose levels, and disruption of insulin secretion is a cause of diabetes. However, it is still unclear how insulin secretion from pancreatic β cells is regulated in vivo and how it is altered by pathological conditions. This study provides new insights into glucose concentration-dependent intracellular Ca2+ dynamics in pancreatic β cells, suggests that mitochondria and endoplasmic reticulum are involved in β cell function, and establishes a new visualization method to witness pancreatic β cell activity in vivo.
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| Free Research Field |
薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、インスリン分泌が膵β細胞内のCa2+濃度によって制御されていることを利用し、全く新たな視点から研究が進められた。膵β細胞のCa2+動態には非常に複雑な機構が関与しているが、それを読み解くための細胞内小器官のCa2+動態を解析する新たな研究方法と、生体内における活動を目の当たりにする新たな可視化法が確立された。このような成果は、今後の研究発展を著しく促進し、糖尿病発症における膵β細胞の機能変化に新たな光を投げかけるものと期待される。
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