Immune regulation by crosstalk between dendritic cells and regulatory T cells

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H03469
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 49030:Experimental pathology-related
• Research Institution: Nagoya City University
• Principal Investigator: Sayuri Yamazaki 名古屋市立大学, 医薬学総合研究院(医学), 教授 (70567255)
• Co-Investigator(Kenkyū-buntansha): 大倉 永也 大阪大学, 大学院医学系研究科, 特任教授(常勤) (20300949)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 樹状細胞 / 制御性T細胞 / 免疫制御

Outline of Final Research Achievements

To investigate the crosstalk between dendritic cells and regulatory T cells, analyzing some mouse models and human sample were perfomed. By analyzing gene expressions using samples and public databases, we found that regulatory T cells not only express Treg-specific genes such as Foxp3 and CTLA-4, but also other unique genes under these conditions. We also fond that a specific featured dendritic-cell subset may be correlated to regulatory T cells. We are continuing the analysis and working on important molecules related to dendritic cell-regulatory T cell crosstalk.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

免疫学の基礎研究は多くの病気に関係するため、色々な病気の新しい治療法や医学の進歩に貢献できる。自らがこれまで発展させてきた樹状細胞と制御性T細胞のクロストークによる免疫制御というアプローチで、研究を進めることで、学術的な進歩や発展に加え、その成果を応用した治療法に結びつく可能性があり、社会的にも意義が高い。将来、少しでも病気に苦しむ患者様の役に立つことを目指し、研究を推進している。