2022 Fiscal Year Final Research Report
Neural activity for reactivating forgotten memories
| Project/Area Number |
20H03551
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 51020:Cognitive and brain science-related
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| Research Institution | Nagoya City University (2021-2022)
Hokkaido University (2020) |
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Principal Investigator |
NOMURA Hiroshi 名古屋市立大学, 医薬学総合研究院(医学), 教授 (10549603)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 記憶・学習 |
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| Outline of Final Research Achievements |
Retrieval impairment is one of the major symptoms of dementia. Unfortunately, there is currently no established treatment for restoring impaired retrieval. However, our previous research has shown promising results with histamine H3 receptor antagonists in restoring forgotten memories, although the mechanism behind this is not fully elucidated. In the present study, we delved deeper into this mechanism and found that administration of the histamine H3 receptor antagonist Pitolisant greatly increased the activity of some neurons in the perirhinal cortex and increased synchronous activity among these neurons.
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| Free Research Field |
神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
記憶の想起障害は認知症を始めとした認知機能障害において重要な症状の１つだが、障害を回復させる治療法は確立していない。治療法の確立には、想起障害が回復するときの神経メカニズムを解明し、そのメカニズムを効率よく活性化・促進することが望ましい。本研究によって、想起障害の回復作用を有するヒスタミンH3受容体拮抗薬投与によって、嗅周皮質の神経活動の変化が明らかになった。今後は、こうした変化を効率よく誘導する方法を見出すことで、より良い治療法の開発に貢献できると考えられる。
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