2022 Fiscal Year Final Research Report
Elucidation of the brain pathology of mental disorders based on the understanding of the process of internalization of social structure into individual mental and brain functions
Project/Area Number |
20H03596
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 52030:Psychiatry-related
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Research Institution | The University of Tokyo |
Principal Investigator |
Kasai Kiyoto 東京大学, 医学部附属病院, 教授 (80322056)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 社会構造 / トラウマ / 思春期 / 脳画像 |
Outline of Final Research Achievements |
The aim of this study was to elucidate the internalizing effects of the social environment on individual mental and brain functioning in adolescents and young adults [AYA] using complementary data from individuals with psychiatric disorders and healthy controls including adolescents recruited from a population-based cohort. To this end, we quantified the traumas (adverse childhood experiences [ACEs]) and social structures to which individuals are exposed and combined them with brain imaging analysis (MRI, near-infrared spectroscopy). The results suggest that trauma and social structure may influence brain morphology and function. It was also suggested that the presence of a help-seeking attitude may mitigate the effects of trauma on brain functional development.
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Free Research Field |
精神神経科学
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Academic Significance and Societal Importance of the Research Achievements |
従来型の精神疾患の脳病態研究は、遺伝的素因(G)と周産期の環境要因(E1)の相互作用影響をモデル化してきたが、不適切な養育態度など児童期の親子関係(E2)や、AYA世代までの都市居住・マイノリティ状況などの社会環境ストレス(E3)が、精神疾患の発症を含む思春期の脳発達に与える影響はほとんど解明されてこなかった。本研究は、トラウマや社会構造が脳形態・機能に影響を与える可能性を示唆するとともに、援助希求態度があることが、トラウマが脳機能に与える影響を緩和する可能性を明らかにしたことで、高い学術的意義を持つとともに、思春期精神保健施策上も重要な社会的意義を持つと考えられた。
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