Elucidation of Maintenance Mechanism of Tissue Regenerative Potential of Bone Marrow Stem Cells by NO-mediated Cell Competition against Particle Radiation Damage

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H03620
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: University of Fukui
• Principal Investigator: MATSUMOTO Hideki 福井大学, 学術研究院医学系部門, シニアフェロー (40142377)
• Co-Investigator(Kenkyū-buntansha): 前田 宗利 公益財団法人若狭湾エネルギー研究センター, 研究開発部, 主任研究員 (20537055) ; 平山 亮一 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 重粒子線治療研究部, 主任研究員(定常) (90435701)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 組織再生能維持機構 / 骨髄幹細胞 / 粒子放射線 / 細胞競合 / 回復動態

Outline of Final Research Achievements

The surviving fraction of bone marrow-derived hematopoietic stem cells/pluripotent progenitor cells in normal mice after a single 5 Gy whole-body irradiation with X-rays, protons, or carbon beams was about 0.03-0.1 at 24 hours after irradiation, about 0.1 at 7 days, and recovered to about 0.2-0.7 after 14 days.
These results suggest that the DNA damage response mechanism is not induced in damaged bone marrow-derived hematopoietic stem cells/pluripotent progenitor cells and is eliminated, and that bone marrow tissue recovery is induced by new bone marrow-derived hematopoietic stem cells/pluripotent progenitor cells after 7 days of irradiation.

Free Research Field

放射線生物学

Academic Significance and Societal Importance of the Research Achievements

X線と比較して、粒子線により損傷した骨髄由来造血幹細胞/多能性前駆細胞の回復が遅延することが示され、粒子線がん治療における治療計画作成時において、照射野内に含まれる骨髄組織の被ばくを極力避けるようにすべきであることが示唆された。