2022 Fiscal Year Final Research Report
Monitoring Tumor Hypoxia and Sensitizing Radiotherapy Effects by Using Hypoxia-Inducible Secreted Proteins
Project/Area Number |
20H03621
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 52040:Radiological sciences-related
|
Research Institution | Kyoto University |
Principal Investigator |
Harada Hiroshi 京都大学, 生命科学研究科, 教授 (80362531)
|
Project Period (FY) |
2020-04-01 – 2023-03-31
|
Keywords | がん / 微小環境 / 低酸素 / マーカー / 増感 |
Outline of Final Research Achievements |
Since cancer cells become radioresistant under hypoxic conditions and cause poor patient prognosis, there is a need to monitor tumor hypoxia differently in each patient and to establish therapies that target tumor hypoxia. In this study, we identified SPINK1 as a protein secreted by hypoxia-stimulated cancer cells and found that its plasma concentration can be used to monitor the hypoxic fraction in tumors, and that inhibition of SPINK1 can enhance therapeutic effect of radiation.
|
Free Research Field |
放射線腫瘍生物学
|
Academic Significance and Societal Importance of the Research Achievements |
悪性固形腫瘍(がん)の内部に存在する低酸素環境は、がんの悪性化を引き起こす問題として認識されている。本研究で見出した知見により、血漿内のSPINK1濃度を指標に腫瘍内低酸素画分の多いがん患者を選出し、SPINK1を標的とする治療により放射線治療の効果を増強する、個別化医療の実現に繋がる可能性がある。
|