2022 Fiscal Year Final Research Report
Role of Pin1 in the muscle function and metabolic regulation
| Project/Area Number |
20H03732
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中津 祐介 広島大学, 医系科学研究科(医), 准教授 (20452584)
山本屋 武 広島大学, 医系科学研究科(医), 助教 (50760013)
神名 麻智 広島大学, 医系科学研究科(医), 助教 (10619365)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Pin1 / 筋肉 / 脂質代謝 |
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| Outline of Final Research Achievements |
Pin1 play an important role on the process of cell growth and metabolic regulation. We revealed that muscle Pin1 contribute to the enhancement of power and endurance of muscle function. In terms of its underlying mechanism, we identified Calsequestrin 1 (CASQ1) and SERCA1 as novel Pin1 target proteins.
In addition, we demonstrated that Pin1 binds to the enzymes of lipid metabolism such as ACC1, FASN1 and ATGL. By altering such enzymes, Pin1 induces the accumulation of lipid in adipocytes and livers. Such mechanism is related to the pathogenesis of obesity-related disorders, including diabetes mellitus and NASH. Therefore, we speculate that Pin1 inhibitors could be a novel drug to treat these disesases.
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| Free Research Field |
病態生化学
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| Academic Significance and Societal Importance of the Research Achievements |
我々は、Pin1が筋肉の機能や各種臓器における脂肪蓄積に関与することを見出して報告した。これらの結果は、Pin1の機能を変化させることで、治療方法になりうることを示唆するものである。実際、我々は、その目的で多数の新規PIn1阻害薬の合成を続けており、臨床応用を目指している。もし、実用化できれば、社会的な有用性は非常に高いことから、本研究の意義は、学術的な面に留まらず、社会的にも大きなものと考えられる。
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