2022 Fiscal Year Final Research Report

Interdisciplinary study on the peritoneal metastasis of patients with ovarian cancer based on the adipo-peritoneal crosstalk

Research Project

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Project/Area Number	20H03824
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Nagoya University
Principal Investigator	Kajiyama Hiroaki 名古屋大学, 医学系研究科, 教授 (00345886)
Co-Investigator(Kenkyū-buntansha)	芳川修久名古屋大学, 医学部附属病院, 講師 (60804747) 柴田清住藤田医科大学, 医学部, 教授 (90335026) 吉原雅人名古屋大学, 医学部附属病院, 病院助教 (00878374)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	卵巣癌 / 腹膜播種 / 脂肪細胞 / 中皮細胞
Outline of Final Research Achievements	In outcomes of this study, we investigated impact on the malignancy of ovarian cancer cells due to adipose-derived mesenchymal stem cells (ADSC) sourced from the omentum, through our unique ceiling culture method. We successfully demonstrated that proliferation of ovarian cancer cells, the enhanced motility of cancer cells, and the increased ability to form tumors in vivo, were all induced. We reported these series of results in a research paper. Moreover, we have previously identified that ovarian cancer-associated peritoneal mesothelial cells (OCAM) deeply contribute to progression of advanced ovarian cancer in the peritoneal microenvironment. We demonstrated that calcitriol (vitamin D) is a promising candidate substance to inhibit the process of normal peritoneal mesothelial cells transforming into OCAM, and reported these findings in a research paper as well.
Free Research Field	婦人科腫瘍
Academic Significance and Societal Importance of the Research Achievements	卵巣癌大網播種巣で腫瘍増殖が進むメカニズムの一因として、卵巣癌が大網の脂肪細胞に働きかけて脱分化を誘導し、自らの増殖をサポートする細胞を作り出している可能性があることが判明した。この脱分化プロセスを標的とした新規治療戦略を構築できれば、既存の治療戦略とは異なる新たな治療戦略になると考える。またVitamin Dによる腹膜環境の正常化が卵巣癌腹膜播種の新規治療法となる可能性が動物実験を含む様々な実験により明らかになった。癌を標的とした化学療法や分子標的薬などの治療法との相乗効果も期待され、Vitamin D製剤はすでに臨床使用されている安全な薬剤であり、臨床的な効果の検証が期待される。