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2022 Fiscal Year Final Research Report

Optogenetic regulation of function, regeneration and diseases of the female reproductive organ using stem cell and genome editing technologies

Research Project

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Project/Area Number 20H03826
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionKeio University

Principal Investigator

MARUYAMA Tetsuo  慶應義塾大学, 医学部(信濃町), 准教授 (10209702)

Co-Investigator(Kenkyū-buntansha) 佐藤 守俊  東京大学, 大学院総合文化研究科, 教授 (00323501)
高尾 知佳  慶應義塾大学, 医学部(信濃町), 共同研究員 (40612429)
升田 博隆  慶應義塾大学, 医学部(信濃町), 講師(非常勤) (80317198)
内田 浩  慶應義塾大学, 医学部(信濃町), 講師 (90286534)
宮崎 薫  慶應義塾大学, 医学部, 研究員 (90445370)
Project Period (FY) 2020-04-01 – 2023-03-31
Keywords光遺伝学 / ゲノム編集 / 幹細胞 / 再生医学 / 子宮 / 子宮内膜症 / 子宮筋腫 / 子宮内膜癌
Outline of Final Research Achievements

In this study we aimed to optogenetically regulate the function, regeneration, diseases of the female reproductive organ with the combinatory use of stem cell biology, genome editing technology, and tissue engineering. As a result, we were able to control embryo implantation, one of the important uterine functions, in a spatiotemporal manner through optogenetic genome editing of a molecule essential for implantation in mice. To achieve an efficient introduction of the optogenetic system into the tissue and organ, we developed a novel bioengineering method for the partial regeneration of the uterus in rats. To obtain the basis for the optogenetic regulation of the genesis and progression of uterus-associated disorders, we explored the roles of stem cells and genomic abnormalities in the pathogenesis of endometriosis, endometrial cancer, and leiomyoma.

Free Research Field

生殖医学

Academic Significance and Societal Importance of the Research Achievements

本研究において示された光照射による着床制御は,不妊症,不育症,および子宮に関連する周産期疾患や腫瘍性疾患に対する光照射治療という新しい治療様式・戦略を提示することに加えて,その実現化に向けての基盤となる成果である.さらに,時空間的な現象である着床を光照射のオンオフで自在に解析できる新しい研究手法であることと,その結果もたらされ得る着床のメカニズムのさらなる解明が期待できる点で学術的意義が高い.新しい子宮の再生・再建技術ならびに子宮関連疾患における幹細胞とゲノム異常の役割の解明は,光照射治療の実現化に向けての科学的根拠と技術基盤を与えうる点でも学術的社会的意義が高い成果である.

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Published: 2024-01-30  

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